ShanghaiJune 3, 2026 /PRNewswire/ — On June 1, 2026 (Eastern Daylight Time, EDT) at the ASMS conference, SCIEX, a global leader in life science analytical technology and a Danaher company, announced a platform-level upgrade for its high-resolution mass spectrometry platform, the ZenoTOF series. This upgrade encompasses innovations in SCIEX OS 5.0 software, broader front-end compatibility, and future-oriented software ecosystem collaborations, aimed at helping omics researchers tackle complex biological questions. By building a highly interconnected analytical environment, the ZenoTOF platform can significantly reduce workflow complexity and unlock deeper, actionable data insights on a single dynamic platform.
SCIEX ZenoTOF Platform-Level Evolution
SCIEX OS 5.0 software introduces several new features, including Central Metrics Tracker, Central Monitoring, Reporter Template Creator, an AI-powered helpme function, and AI Calculated Columns, comprehensively enhancing data management and analysis efficiency.
ZT Scan DIA 3.0
Combining the comprehensiveness of data-independent acquisition (DIA) with narrower Q1 isolation windows allows researchers to flexibly balance selectivity, sensitivity, and throughput based on experimental needs. This technology provides critical support for scalable proteomics and highly robust metabolomics, further reducing workflow complexity and expanding the application boundaries of a single platform.
Enhanced Sensitivity Mode for the ZenoTOF 8600 System
In Enhanced Sensitivity Mode, the ZenoTOF 8600 demonstrates significant performance improvements in low-sample-volume proteomics studies under nanoflow conditions, achieving approximately 10%–40% increases in both protein identification and quantification results.
Expanded front-end compatibility further enhances the flexibility of the ZenoTOF product line:
Integration of ZenoTOF 8600 with the Echo® MS+ System
Creating the industry’s highest-throughput high-resolution mass spectrometry platform, with sampling speeds of up to 1 sample per second. This solution offers higher sensitivity in high-throughput screening, becoming a core screening technology for accelerating early discovery, reducing workflow complexity, and lowering consumable costs.
HDX-MS Solution Provided by Trajan Scientific and Medical
Combining advanced automation capabilities with comprehensive data processing workflows to help deeply analyze protein structure and binding characteristics. This solution synergizes with the ZenoTOF platform’s electron-activated dissociation (EAD) fragmentation technology to form an end-to-end HDX-MS solution, achieving high sensitivity, zero scrambling, and amino-acid-level structural resolution.
New Ion Source Upgrade
Enabling seamless compatibility between ZenoTOF and Evosep, as well as IonOpticks. Researchers can fully leverage the Whisper Zoom method on a unified SCIEX platform to combine high sensitivity, high robustness, and high throughput, accelerating next-generation proteomics research. Additionally, SCIEX has partnered with IonOpticks to further expand access to advanced liquid chromatography solutions in the proteomics field, including key technologies like the Aurora XS column.
Through deep collaborations with leading life science software platforms, researchers can seamlessly conduct research within their established and trusted workflows, achieving more efficient data analysis and outcome translation:
Strategic Collaboration with BSI
Deeply integrating the leading AI-driven proteomics analysis software PEAKS into the ZenoTOF product line, enabling an integrated analysis workflow from biomarker discovery and quantification to validation. This solution breaks the traditional fragmented “discovery-targeted quantification” work mode, significantly reducing workflow complexity and enhancing data consistency and reproducibility in translational research.
MS-DIAL as One of the First Partners
Helping transform ZT Scan DIA 3.0 data acquisition results into interpretable life science insights. Through this widely used metabolomics and lipidomics analysis platform, users can efficiently discover new biomarkers and deepen systemic understanding.
Through Collaboration with MZIO
Achieving full compatibility between SCIEX data and the mzmine platform, allowing users to seamlessly integrate SCIEX systems into existing metabolomics and small molecule analysis workflows, supporting scalable data processing, advanced feature extraction, and downstream analysis across diverse mass spectrometry workflows.
Dr. Jose Castro-Perez, Vice President of Product Management at SCIEX, stated that what we are bringing is not just incremental performance improvements, but a transformation in how researchers conduct work across the entire omics workflow. This is only the beginning. Our commitment is clear: through this continuously evolving platform, we will drive ongoing innovation and create long-term value for customers across various workflows.
About SCIEX
SCIEX is dedicated to providing solutions for precise detection and compound quantification, helping our customers protect and improve human health and safety. We have over 50 years of innovation experience in mass spectrometry technology. Since successfully launching the first commercial SCIEX triple quadrupole mass spectrometry system in 1981, we have been committed to developing breakthrough technologies and solutions that influence and advance scientific research and outcomes that improve people’s lives.
Today, as part of Danaher Corporation (NYSE: DHR), a global life science and technology innovator, SCIEX continues to develop robust solutions in mass spectrometry and capillary electrophoresis technology. We help customers monitor environmental hazards and respond quickly; better understand diseases and disease markers, improve clinical treatment of diseases, and support the development and approval of related drugs; and ensure food is healthier and safer.